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Education
- Harvard Medical School – MD
- Massachusetts General Hospital School – Internship in Internal Medicine
- Dartmouth-Hitchcock Medical Center, Hanover, New Hampshire – Residency in Internal Medicine
- Massachusetts General Hospital School – Clinical Fellowship in Medicine, Endocrine
- Harvard Medical School – Research Fellow in Medicine
- The Role of Nuclear Phosphoinositides in the p53-MDM2 Nexus
- Regulation of the MDM2-p53 nexus by a nuclear phosphoinositide and small heat shock protein complex
- Agonist- and stress-driven compartmentalized phosphoinositide signaling in cells
- The poly(A) polymerase Star-PAP is regulated by stably associated phosphoinositide messengers
- Regulation of NRF2 by stably associated phosphoinositides and small heat shock proteins in response to stress
- Regulation of the MDM2-p53 Nexus by a Nuclear Phosphoinositide and Small Heat Shock Protein Complex
- The nuclear phosphoinositide-p53 signalosome in the regulation of cell motility
- Phosphoinositide signaling at the cytoskeleton in the regulation of cell dynamics
- Phosphoinositide signalling in cell motility and adhesion
- Haem biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue
- Linking Phosphoinositides to Proteins: A Novel Signaling PIPeline
- Regulation of the poly(A) Polymerase Star-PAP by a Nuclear Phosphoinositide Signalosome
- A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism
- Nuclear phosphoinositide signaling promotes YAP/TAZ-TEAD transcriptional activity in breast cancer
- Environmental pollutants and phosphoinositide signaling in autoimmunity
Dr. Cyrns is a physician-scientist who focuses on understanding how cancer cells adapt to and survive metabolic stress caused by their rapid growth. He and colleague Richard Anderson, PhD, lead a team of scientists together with who have discovered new signaling pathways (“third messengers”) in the nucleus of cells that protect tumor cells from cellular stress.
Drs. Cryns and Anderson investigate how lipid second messengers typically associated with membranes modify the functions of proteins inside the nucleus of cells, so-called “third messenger” pathways. Our joint lab is the Third Messenger Lab.
One example of the third messenger pathway is the discovery that second messengers are linked to the p53 tumor suppressor protein to activate Akt in the nucleus and protect cells from dying, directly linking the p53 and Akt pathways for the first time.