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Madison WI 53705-2281
Dr. Michelle Kimple is a faculty member in the Division of Endocrinology, Diabetes & Metabolism within the Department of Medicine and has an affiliate appointment in the Department of Cell and Regenerative Biology. She is Director of the Basic Science Selective, Department of Academic Affairs and a Research Health Scientist at the William S. Middleton Memorial Veteran’s Hospital. Dr. Kimple is heavily involved in the training of future researchers and physician-scientists, and currently serves as a faculty trainer on over five NIH T-32 training grants. She is a member of numerous professional organizations such as The Endocrine Society, the American Diabetes Association, and the American Physiological Society. Among the many awards Dr. Kimple has received are the Department of Medicine’s Puestow Research Award, awarded to a junior member of the Medicine faculty who has made a significant research contribution towards advancing the field of medicine, and the Vilas Life Cycle Professorship from the UW-Madison Women in Science & Engineering Leadership Institute and Office of the Provost.
University of North Carolina – Chapel Hill, Chapel Hill, North Carolina – PhD in Biochemistry and Biophysics
Duke University, Durham, North Carolina – Post doctorate fellowship in Pharmacology and Islet Biology
- Free fatty acid receptor 4 agonists stimulate insulin secretion via different mechanisms in mouse versus human islets
- Characterizing Plasma-Based Metabolomic Signatures for Metastasis in Non-Small Cell Lung Cancer
- Gα<sub>z</sub>-independent and -dependent Improvements With EPA Supplementation on the Early Type 1 Diabetes Phenotype of NOD Mice
- The prostaglandin E<sub>2</sub> EP3 receptor has disparate effects on islet insulin secretion and content in β-cells in a high-fat diet-induced mouse model of obesity
- EP3 signaling is decoupled from the regulation of glucose-stimulated insulin secretion in β-cells compensating for obesity and insulin resistance
- What the BTBR/J mouse has taught us about diabetes and diabetic complications
- How my bipolar diagnosis changed my scientific career
- Metformin Monotherapy Alters the Human Plasma Lipidome Independent of Clinical Markers of Glycemic Control and Cardiovascular Disease Risk in a Type 2 Diabetes Clinical Cohort
- Plasma Prostaglandin E<sub>2</sub> Metabolite Levels Predict Type 2 Diabetes Status and One-Year Therapeutic Response Independent of Clinical Markers of Inflammation
- A human pancreatic ECM hydrogel optimized for 3-D modeling of the islet microenvironment
- Effects of Arachidonic Acid and Its Metabolites on Functional Beta-Cell Mass
- Pharmacological blockade of the EP3 prostaglandin E<sub>2</sub> receptor in the setting of type 2 diabetes enhances β-cell proliferation and identity and relieves oxidative damage
- Human Islet Expression Levels of Prostaglandin E<sub>2</sub> Synthetic Enzymes, But Not Prostaglandin EP3 Receptor, Are Positively Correlated with Markers of β-Cell Function and Mass in Nondiabetic Obesity
- Prostaglandin EP3 receptor signaling is required to prevent insulin hypersecretion and metabolic dysfunction in a non-obese mouse model of insulin resistance
- The influence of intermittent hypoxia, obesity, and diabetes on male genitourinary anatomy and voiding physiology
Dr. Kimple leads a multi-level research team whose focus is on understanding how the beta-cells of the pancreas respond to nutrient and hormonal stimulation to affect biological changes. Her group is especially interested in elucidating how dysfunctional G protein-coupled receptor signaling pathways contribute to the pathogenesis of type 1 and type 2 diabetes and in translating these insights into new and improved diabetes therapeutics. Dr. Kimple’s research has been funded almost continuously from her PhD onwards by the National Institutes of Health and the Juvenile Diabetes Research Foundation, among other agencies. Her work has been featured in several university press releases and patent applications. Dr. Kimple has been the recipient of several awards, including a Preparing Future Faculty Fellowship from Duke University, where she learned the skills necessary to be a successful mentor and teacher while maintaining a top-tier research laboratory.
Impact Award, UW SMPH Group on Women in Medicine and Science (2024)
Research Center Scientist Award, Department of Veterans Affairs (2024)
Vilas Life Cycle Professorship (2023)
Department of Medicine Puestow Research Award (2016)