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2178 Wisconsin Institute for Discovery
330 N. Orchard St. Madison, WI 53715
B.S. 1988, University of Wisconsin-Madison
Ph.D. 1993, Texas A & M University (Paul F. Fitzpatrick)
Postdoctoral 1993-96, University of Michigan Medical School (Jack E. Dixon)
- A needed nomenclature for nucleosomes
- Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease
- Gut microbiota-derived metabolite trimethylamine N-oxide alters the host epigenome through inhibition of S-adenosylhomocysteine hydrolase
- H2A.Z deposition by the SWR complex is stimulated by polyadenine DNA sequences in nucleosomes
- Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease
- The role of ATP citrate lyase in myelin formation and maintenance
- Protein restriction slows the development and progression of pathology in a mouse model of Alzheimer's disease
- Nucleic acid sequence contributes to remodeler-mediated targeting of histone H2A.Z
- Individual dietary amino acid restrictions induce distinct metabolic and chromatin states
- DOT1L is a barrier to histone acetylation during reprogramming to pluripotency
- Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide-Activated Sirtuin 7
- Protein restriction slows the development and progression of Alzheimer's disease in mice
- The citrate transporters SLC13A5 and SLC25A1 elicit different metabolic responses and phenotypes in the mouse
- Development of a multiplex assay to assess activated p300/CBP in circulating prostate tumor cells
- Intrinsic catalytic properties of histone H3 lysine-9 methyltransferases preserve monomethylation levels under low S-adenosylmethionine
The Denu Lab investigates the intersections between metabolism and the epigenome, a complex series of modifications made on top of the genome that regulates gene expression. Cell metabolism includes the many biochemical reactions that create energy and build crucial molecules for the cell. Epigenetics is the study of modifications to the DNA and histone proteins, which package DNA in the nucleus. Merging these two concepts, we study how the daily workings of the cell affect the folding and accessibility of DNA, influencing how our cells and ultimately body responds to changes in diet or lifestyle. Our interdisciplinary approach spans basic biochemistry to big data, using methods ranging from in vitro enzyme assays to high-throughput mass spectrometry. The Denu lab is part of the Microbiome, Epigenetics, and Multi-omics hubs at the Wisconsin Institute for Discovery, and is involved in many collaborations both on and off campus.
2001 Research Scholar Award (American Cancer Association)
2002 Awarded Indefinite Tenure (OHSU)
2003 Awarded Indefinite Tenure (University of Wisconsin-Madison)
2006 Romnes Fellow, University of Wisconsin
2010 Theme Director, Wisconsin Institute for Discovery
2011 Elected Fellow of the AAAS
2013 NIH MERIT Award
2016 Kellett Award, University of Wisconsin-Madison
2016 Mid-career Vilas Award, University of Wisconsin-Madison
2019 Ride Scholar, University of Wisconsin-Madison
2021 ASBMB Fellow
2023 Katherine Burns Van Donk Steenbock Professorship in Nutrition, University of Wisconsin