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Beth has a B.S. in Dietetics from the University of Wisconsin-Stout, an M.S. in Nutritional Sciences from the University of Georgia, and is a Registered Dietitian.
Adipogenesis is a complex and coordinated process driven by peroxisome proliferator-activated receptor gamma (PPARy). In a genetically diverse mouse population, our lab identified an epistatic interaction associated with fat mass gain between PPARy and MMADHC (CblD). CblD is a vitamin B12 trafficking protein that is essential for the delivery of vitamin B12 to methylmalonyl CoA mutase and methionine synthase. However, the role of CblD during the process of adipogenesis has not been investigated. The aim of my research is to determine the role and mechanisms of CblD and its interaction with PPARy in adipocyte biology.