Cacious Black Phiri

    PhD Student in the Tanumihardjo Research Group

    Interaction of vitamin A with vitamin D and calcium on bone outcomes in swine

    Cacious has an MSc. in Human Nutrition and a BSc. in Agriculture majoring in Nutrition and Food Science both from the University of Malawi. During his master’s program, Cacious investigated the effectiveness of nutrition counseling in promoting optimal child feeding practices. Cacious worked as a Nutrition Officer in the Department of Nutrition, HIV and AIDS providing nutrition policy direction in the implementation of nutrition programs in Malawi. As a coordinating office, he provided support to ministries of Agriculture and Food Security; Health and Population; Gender, Children and Disability; Education; and the Non-Governmental Organizations. To achieve this mandate, Cacious conducted capacity building exercises through trainings, and mentorship. He has contributed to developing national documents in nutrition, food security, hygiene & sanitation, and early childhood development. His job saw him interacting with development partners, non-governmental organizations, and the donor community. His areas of focus were maternal & child nutrition, and the school feeding program. He has also worked with the University of Malawi as a lecturer in human nutrition and participated in curriculum review in addition to teaching and supervising students’ research. As a PhD candidate, Cacious is destined to graduate in December 2025.

    Excessive retinoic acid competes with calcitriol (1,25(OH)2D3) for the shared heterodimer retinoid X receptor and creates its functional deficiency. Calcitriol mediates intestinal calcium absorption through a cascade of events leading to an increase in the transcription, translation, and expression of calcium transporters. By creating functional deficiency of calcitriol, high VA impairs calcium absorption leading to bone resorption. The objective of the study is to investigate whether high vitamin D intake or high calcium intake can mitigate the negative impacts of high vitamin A intake. In the systematic review and meta-analysis, potential reference ranges will be calculated from swine getting adequate vitamin A based on reference from either the industry requirements or the National Research Council.

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    Dean’s Honor Roll, 4th year, second semester.