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Veterans Administration Hosp
2500 Overlook Ter D4243
Madison WI 53705-2254
Dr. Konopka is a faculty member in the Division of Geriatrics and Gerontology within the Department of Medicine. He is an editorial board member for the Journal of Applied Physiology and a member of the Gerontological Society of America, American College of Sports Medicine and American Physiological Society. Dr. Konopka has been selected as a reviewer for several journals including Journal Gerontology: Biological Sciences, Aging Cell, GeroScience, Science Advances, Scientific Reports, and Journal of Physiology.
Ball State University, Muncie, IN – PhD in Human Bioenergetics
Mayo Clinic College of Medicine, Rochester, MN – Postdoctoral Fellowship in Diabetes, Nutrition and Endocrinology
Colorado State University, Fort Collins, CO – Postdoctoral Fellowship in Aging and Age-Related Disease
- Tissue-Specific Effects of Dietary Protein on Cellular Senescence Are Mediated by Branched-Chain Amino Acids
- Rapamycin Does Not Compromise Exercise-Induced Muscular Adaptations in Female Mice
- Metformin suppresses the mitochondrial and transcriptional response to exercise, revealing a conserved BCL6B-associated angiogenic program
- Rapamycin does not compromise physical performance or muscle hypertrophy after PoWeR while intermittent rapamycin alleviates glucose disruptions by frequent rapamycin
- PoWeR elicits intracellular signaling, mitochondrial adaptations, and hypertrophy in multiple muscles consistent with endurance and resistance exercise training
- Tissue-specific effects of dietary protein on cellular senescence are mediated by branched-chain amino acids
- The Fifth Annual Symposium of the Midwest Aging Consortium
- Inhibition of mTORC1 by rapamycin results in feedback activation of Akt<sup>S473</sup> and aggravates hallmarks of osteoarthritis in female mice and non-human primates
- The common marmoset as a translational model of age-related osteoarthritis
- Geroprotector drugs and exercise: friends or foes on healthy longevity?
- Resistance exercise protects mice from protein-induced fat accretion
- The Third Annual Symposium of the Midwest Aging Consortium
- Blazing a trail for the clinical use of rapamycin as a geroprotecTOR
- Cycle exercise training and muscle mass: A preliminary investigation of 17 lower limb muscles in older men
- Small-Scale Randomized Controlled Trial to Explore the Impact of β-Hydroxy-β-Methylbutyrate Plus Vitamin D<sub>3</sub> on Skeletal Muscle Health in Middle Aged Women
Dr. Konopka uses a translational research approach that identifies mechanisms regulating the biology and metabolism of musculoskeletal aging in pre-clinical models and applies these findings to test the potential healthspan extending effects in human clinical trials. Dr. Konopka’s research has two main themes that focus on the age-related loss of skeletal muscle health and osteoarthritis. We are currently investigating how skeletal muscle mitochondrial bioenergetics and remodeling mediate aging and the healthspan extending effects of exercise and/or metformin. We are also interested in understanding how the mTOR signaling pathway is involved in the initiation and treatment of osteoarthritis.