Nate Willis

    MANTP Postdoctoral Trainee

    Investigating enterohepatic metabolism and dysfunction in preclinical models of parenteral and enteral nutrition

    Nate began his career in 2010 with a B.S. in Hospitality Administration from Boston University before embarking on a foodservice career as a Chef, Institutional Foodservice Manager, and Food Educator. In 2023, he received his Ph.D. from the University of Illinois Urbana-Champaign where he also studied to become a Registered Dietitian. Since joining MANTP as a Postdoc in 2023, Nate has worked to develop a novel murine model of cycling parenteral nutrition with which to investigate the metabolic effects of infusion cycling on hepatic outcomes. He also supports a wide range of gut micro- and mycobiome projects with his bioinformatic analytical skills. In his free time, Nate enjoys gardening, cycling, and his futile attempts to train his wife’s cat.

    Parenteral Nutrition is a lifesaving therapy when enteral use is contraindicated. This need for parenteral nutrition may arise due to gastrointestinal disease and congenital defects. Despite its necessity, extended use of PN contributes to hepatic disease presenting with features of steatosis and cholestasis. This can progress to fibrosis and end-stage liver disease if not managed. The treatments for this condition remain empiric and fail to address the underlying causes. As such, my work aims to explore metabolic underpinnings of chronic parenteral nutrition and unveil therapeutic opportunities that contribute to prevention of disease and preservation of patient quality of life.

    Click here for graphical abstract

    2025 Excellence in Mentoring Award – UW Postdoctoral Association
    2025 GI-Liver Section Trainee Poster Award – APS Summit